Metabolic Syndrome Parameters, Determinants, and Biomarkers in Adult Survivors of Childhood Cancer: Protocol for the Dutch Childhood Cancer Survivor Study on Metabolic Syndrome (Dutch LATER METS)

Background Potential late effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia, and hypertension. These risk factors cluster together as metabolic syndrome increase the development diabetes mellitus cardio- cerebrovascular disease. Knowledge on factors, timely diagnosis, preventive strategies is importance to prevent complications improve quality life. Currently, no national cohort studies prevalence determinants in survivors, including biomarkers genetic predisposition, are available. Objective The objectives Dutch LATER METS study assess 1) its separate components, 2) potential diagnostic predictive value additional surveillance adult long-term survivors cancer. Methods This a cross-sectional based recruitment all treated Netherlands between 1963 2002. Metabolic will be classified according definitions third Adult Treatment Panel Report National Cholesterol Education Program well Joint Interim Statement compared reference data. Dual-energy x-ray absorptiometry scans were performed body composition more detail. effect patient characteristics, previous treatment, variation assessed. novel tested. Results Patient accrual started 2016 lasted until April 2020. A total 2380 from 7 pediatric oncology hospitals have participated. From July 2020, biomarker testing, single nucleotide polymorphism analysis, data analysis performed. Conclusions provide knowledge clinical survivors. results this used optimize guidelines enhanced stratification screening strategies. diagnosis complications. International Registered Identifier (IRRID) DERR1-10.2196/21256